Interaction with Disease This medication interacts with impaired liver function, depression and glaucoma. Manufacturer advises avoid with concurrent use of potent inhibitors of CYP3A4 except in patients verified to be extensive CYP2D6 metabolisers where manufacturer recommends max. Patient-reported outcome-defined level of clinical benefit Three of the RCTs in Table 3 also reported a predefined composite clinical outcome as a measure of clinical benefit following dapoxetine treatment. If you are taking any other medicines. Before taking dapoxetine Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Furthermore, one of these studies also found significant differences between dapoxetine both 30 mg and 60 mg and placebo at all time points between baseline and end-of-study. · Dapoxetine oral. Updated 2 Feb | Selective serotonin re-uptake inhibitors Premature ejaculation. Share. Check interactions. Drugs List. Therapeutic Indications. Dosage. Contraindications. Precautions and Warnings. Dapoxetine, marketed as Priligy, among others, is a medication used for the treatment of premature ejaculation (PE) in men 18–64 years old. [3] [4] [5] Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. [6]. Dapoxetine is prescribed for the treatment of premature ejaculation. Take one tablet hours before you have sex. The most common side-effects include feeling dizzy or faint, and feeling sick (nausea). Drinking a full glass of water at the same time as taking the tablet can reduce these effects.