How much is your partner bothered by premature ejaculation? With premature ejaculation, you might feel that you lose some of the closeness shared with a sexual partner. Agents for the treatment of erectile dysfunction should be used with caution in patients with anatomical deformation of the penis angulation, cavernosal fibrosis, or Peyronie’s disease , or in patients who have conditions which may predispose them to priapism sickle cell anemia, multiple myeloma, leukemia. What sites do you recommend visiting? It involves stopping sexual stimulation just before ejaculation. If you miss a dose, skip it and continue with your normal schedule. · The dapoxetine/ sildenafil combination therapy significantly improves the IELT values and patient reported outcome measures of PE patients who also suffer from . Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients . rows · Dapoxetine is a selective serotonin reuptake inhibitor used in the treatment of premature ejaculation. Generic Name Dapoxetine DrugBank Accession Number.