Contraindications and cautions Do not prescribe a phosphodiesterase-5 PDE-5 inhibitor to a man with: Unstable angina or angina occurring during sexual intercourse. See the section on Cardiac risk stratification for more information. Regular or intermittent use of nitrates in any form — risk of severe, life-threatening hypotension. The manufacturer advises that prescribers should avoid concomitant prescribing. Hypotension systolic blood pressure below 90 mmHg.
· Sildenafil is used to treat men who have erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called phosphodiesterase .
Do not use more of it and do not use it more often than your doctor ordered. If too much is used, the chance of side effects is increased. This medicine comes with a patient information leaflet.
Read and follow these instructions carefully before you start using sildenafil and each time you get a refill of your medicine. Ask your doctor if you have any questions.
Sildenafil belongs to a group of medicines called phosphodiesterase 5 PDE5 inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works.
· Before taking this medicine. You should not use sildenafil if you are allergic to it, or: if you take other medicines to treat pulmonary arterial hypertension, such as .
Benjamin P. Smith1; Mary Babos2. Continuing Education Activity Sildenafil is a medication used in the management and treatment of erectile dysfunction and pulmonary arterial hypertension.
It is in the phosphodiesterase-5 inhibitor PDE5-I class of medications. This activity describes the indications, actions, adverse effects, and contraindications of sildenafil as an agent in the clinical setting. Objectives: Explain the mechanism of action of sildenafil in the treatment of erectile dysfunction and pulmonary arterial hypertension.
Describe the clinically important drug interactions of sildenafil.
The decrease in blood pressure was most notable approximately 1 to 2 hours after dosing and was not different from placebo at 8 hours. Similar effects on blood pressure were noted with 25 mg, 50 mg, and mg doses of sildenafil, therefore the effects are not related to dose or plasma levels within this dosage range.
Larger effects were recorded among patients receiving concomitant nitrates [see Contraindications 4 ]. Single oral doses of sildenafil up to mg in healthy volunteers produced no clinically relevant effects on electrocardiogram ECG. After chronic dosing of 80 mg three times a day to patients with PAH, no clinically relevant effects on ECG were reported.
· Proper Use Drug information provided by: Merative, Micromedex ® Use sildenafil exactly as directed by your doctor. Do not use more of it and do not use it .
Brand names Why is this medication prescribed? Sildenafil Viagra is used to treat erectile dysfunction impotence; inability to get or keep an erection in men. Sildenafil Liqrev, Revatio is used to improve the ability to exercise in adults Liqrev, Revatio and children 1 year of age and older Revatio with pulmonary arterial hypertension PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness.
Sildenafil is in a class of medications called phosphodiesterase PDE inhibitors. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Sildenafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow easily.
If you are taking sildenafil to treat erectile dysfunction, you should know that it does not cure erectile dysfunction or increase sexual desire.
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Sildenafil should be used with caution in men taking an alpha-blocker (especially doxazosin). Hypotension is more likely to occur within four hours following treatment with .
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